Anti-PIVKA II antibody [1C5] (bc06701)
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Description: Mouse monoclonal [1C5] to PIVKA II
Cat. NO. bc06701
Target: Human PIVKA II
Clone: 1C5
Isotype: IgG1
Applications: CLIA
Clinical area: Diagnosis of hepatocellular carcinoma
Anti-PIVKA II antibody [1C5] (bc06701)
Monoclonal antibodies
Format: Unconjugated, Unmodified
Size: 0.2mg, 1mg, 10mg
Price range: $219.00 through $9,699.00
Description
Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II), also known as Des-γ-carboxy-prothrombin (DCP), is an abnormal form of prothrombin. Normally, the prothrombin’s 10 glutamic acid residues (Glu) in the γ-carboxyglutamic acid (Gla) domain at positions 6, 7, 14, 16, 19, 20,25, 26, 29 and 32 are γ-carboxylated to Gla by vitamin-K dependent γ- glutamyl carboxylase in the liver and then secreted into plasma. In patients with hepatocellular carcinoma (HCC), γ-carboxylation of prothrombin is impaired so that PIVKA-II is formed instead of prothrombin. PIVKA-II is considered as is an efficient biomarker specific for HCC.
Contact our Technical Service Department for more information on how to receive a FREE 10 µg sample of PIVKA-II [1C5], mAb, Mouse: bc06701
Overview
| Product name | Anti-PIVKA II antibody [1C5] |
|---|---|
| Description | Mouse monoclonal [1C5] to PIVKA II See all PIVKA II primary antibodies |
| Host species | Mouse |
| Tested applications | Chemiluminescent Immunoassay (CLIA) |
| Species reactivity | Reacts with: Human |
| Production | Cultured in vitro under conditions free from animal-derived components. |
Properties
| Form | Liquid |
|---|---|
| Storage instructions | For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles. |
| Storage buffer | PBS, pH 7.4, containing 0.03% Proclin 300. 50 mM Na-citrate, 150 mM NaCl, pH 7.0, containing 0.03% Proclin 300 |
| Concentration | 2 mg/ml |
| Purity | Protein A/G affinity column |
| Clonality | Monoclonal |
| Clone number | 1C5 |
|---|---|
| Isotype | IgG1 |
Matched Antibody Pairs
| Human Target | Capture/Detection Antibody |
|---|---|
| PIVKA II | CLIA (Capture-Detection): 1C5 – 2D7 6C4 – 2D7 2D7 – 6C4 |
Related Products
| Cat. NO. | Description | Clone | Matched Pairs | Application | |
|---|---|---|---|---|---|
| bc06701 | mouse mAb, Anti-PIVKA II antibody | 1C5 | 1C5 – 2D7 | CLIA |  |
| bc06702 | mouse mAb, Anti-PIVKA II antibody | 2D7 | 2D7 – 6C4 | CLIA | |
| bc06703 | mouse mAb, Anti-PIVKA II antibody | 6C4 | 6C4 – 2D7 | CLIA | |